How long does osmoprep last

Purchase the following items from your pharmacy. A written prescription from your physician is not required:. No solid foods, milk or milk products. In the evening, at 6 p. Drink an 8 oz. Five 5 hours before your scheduled arrival time, you need to drink the entire content of the second bottle of magnesium citrate, and one 8 oz. You should not have anything else to drink or eat until after your procedure except the approved medications with a small sip of water.

You must have a friend or family member available to provide you with transportation to the and from the procedure. For more information about ASGE, visit www. This information is intended only to provide general guidance.

It does not provide definitive medical advice. It is important Would you like to switch to the accessible version of this site? Go to accessible site Close modal window. Don't need the accessible version of this site? Hide the accessibility button Close modal window. Accessibility View Close toolbar. Colonoscopy Procedure What is a colonoscopy? On the day of your procedure you can make your gastroenterologist aware of the medication you are taking and the amount you are taking.

If you take a medication to thin your blood such as Coumadin, Plavix, Pradaxa, Lovenox, Xarelto, Eliquis, Brilinta, Effient, Ticlid, Disgren, Pletal… you must be seen in our office prior to your procedure. At the time of your office visit a plan will be made in conjunction with your prescribing physician about use of your blood thinner. Please note that you cannot have any solid foods starting the day before your procedure.

The day of the procedure you may not have gum, mints, ice chips, hard candies or cigarettes. This includes the prep solution. You cannot have anything in your mouth gum, mint, cough drop, ice chips etc. THREE hours before your procedure.

Before the exam: You will change into a gown and robe. Your medical history will be reviewed with you and you will be given a consent form to sign. A nurse will insert an intravenous IV line into your hand or arm. During the exam: Medicine will be given through the IV line to sedate you. Your heart rate and oxygen levels will be monitored. If your blood pressure is low, you may be given fluids through the IV line.

The doctor will insert a flexible tube — called a colonoscope — into your anus and will advance it slowly through the rectum and colon, looking for abnormal tissue or polyps. If abnormal tissue or polyps are found, the doctor may remove them through the colonoscope for closer examination or biopsy. Tissue removal is painless.

What happens after the exam? The doctor will talk with you about the initial results of your exam. The doctor will prepare a full report for the physician who referred you for the colonoscopy. You may feel bloated after the procedure. This is normal. Medication given during the exam will prohibit you from driving for the rest of the day.

Following the exam, you may resume your normal diet. Avoid alcohol until the next day. You may resume your regular activities the day after the procedure. A nurse will provide you with complete discharge instructions before you leave the endoscopy center.

Be sure to ask the nurse for specific instructions if you take blood thinners such as aspirin, Coumadin or Plavix. Any tissue samples or polyps removed during the exam will be sent to a lab for evaluation. It may take working days for you to be notified of the results. Are there possible complications from a colonoscopy?

Risks include: Perforation, or a tear, of the lining of the colon. Bleeding from the biopsy or polypectomy site if tissue was removed. Reaction to medications used during the procedure. Shake until the powder is mixed and chill in the refrigerator. Begin drinking the solution. Drink an 8 ounce glass of the solution every 10 - 15 minutes. It is recommended that you drink the whole glass rapidly rather than sip small amounts. Shake the container before pouring each dose.

Refrigerate the unused portion. Make a conscious effort to drink as much clear liquids as you can before, during and after the preparation.

NOTE: If you experience nausea - slow down your prep intake and walk around until nausea is relieved. Drink an 8 ounce glass of the solution every 10 minutes as directed above. Do not rush. If you need to wait longer between glasses, do so. Keep drinking the solution until the bottle is empty. This solution must be completed at least 3 hours prior to your appointment arrival time.

STEP 2: You may drink clear liquids until 3 hours before your appointment time. You may take your prescription medications except those listed in the booklet with water up to 3 hours before your appointment arrival time.

Do not use smokeless tobacco on the day of your procedure. Starting 3 hours before your appointment arrival time absolutely nothing by mouth including gum, hard candy, breath mints.

Suprep bowel prep Instructions 1. Take the last dose of Miralax in the morning the day before your procedure 4. In the U. There are no data available to assess the presence of sodium phosphate in human milk, the effects of the drug on the breastfed infant, or the effects of the drug on milk production.

No overall differences in safety or effectiveness were observed between geriatric patients and younger patients. However, the mean phosphate levels in geriatric patients were greater than the phosphate levels in younger patients after OsmoPrep administration.

Greater sensitivity of some older individuals cannot be ruled out; therefore, use OsmoPrep with caution in geriatric patients. Advise geriatric patients to adequately hydrate before, during, and after the use of OsmoPrep. Sodium phosphate is known to be substantially excreted by the kidney, and the risk of adverse reactions with sodium phosphate may be greater in patients with impaired renal function.

Since geriatric patients are more likely to have impaired renal function, consider performing baseline and post-colonoscopy labs phosphate, calcium, potassium, sodium, creatinine, and BUN in these patients [see Warnings and Precautions 5. Sodium phosphate is substantially excreted by the kidney. These patients may be at risk for renal injury. Advise these patients of the importance of adequate hydration before, during and after the use of OsmoPrep, and consider performing baseline and post-colonoscopy labs phosphate, calcium, potassium, sodium, creatinine, and BUN in these patients [see Warnings and Precautions 5.

Overdosage of OsmoPrep may lead to severe electrolyte disturbances, including hyperphosphatemia, hypocalcemia, hypernatremia, or hypokalemia, as well as dehydration and hypovolemia, with attendant signs and symptoms of these disturbances.

Certain severe electrolyte disturbances resulting from overdose may lead to cardiac arrhythmias, seizure, renal failure, and death [see Warnings and Precautions 5. Monitor for fluid and electrolyte disturbances and treated symptomatically.

OsmoPrep sodium phosphate monobasic monohydrate and sodium phosphate dibasic anhydrous is an osmotic laxative used to clean the colon prior to colonoscopy. OsmoPrep is manufactured with a highly soluble tablet binder and does not contain microcrystalline cellulose MCC. Each OsmoPrep tablet, for oral administration, contains 1. Inert ingredients include polyethylene glycol , NF; and magnesium stearate, NF.

OsmoPrep is gluten-free. The structural and molecular formulae and molecular weights of the active ingredients are shown below:. The primary mode of action is the osmotic effect of sodium, which induces a laxative effect. The physiological consequence is increased water retention in the lumen of the colon, resulting in loose stools.

Administration of the recommended OsmoPrep dosage regimen has a purgative effect for approximately 1 to 3 hours. Pharmacokinetic studies with OsmoPrep have not been conducted. An open-label pharmacokinetic study of oral sodium phosphate in healthy subjects was performed to determine the concentration-time profile of serum inorganic phosphorus levels after oral sodium phosphate administration.

All subjects received the approved dosing regimen for colon cleansing of 60 grams of sodium phosphate with a total liquid volume of 3. A gram dose 20 tablets given as 3 tablets every 15 minutes with 8 ounces of clear liquids was given beginning at 6 PM in the evening. The gram dose 20 tablets given as 3 tablets every 15 minutes with 8 ounces of clear liquids was repeated the following morning beginning at 6 AM. The serum phosphorus level rose to a mean of 8.

The serum phosphorus level remained above baseline for a median of 24 hours after the administration of the initial dose of sodium phosphate tablets range 16 to 48 hours. The upper 4. Male and Female Patients : No difference in serum phosphate AUC values were observed in the single pharmacokinetic study conducted with sodium phosphate tablets in 13 male and 10 female healthy subjects.

Patients with Renal Impairment : The effect of renal impairment on the pharmacokinetics of OsmoPrep has not been studied. The inorganic form of phosphate in the circulating plasma is excreted almost entirely by the kidneys [see Warnings and Precautions 5.

The colon cleansing efficacy and safety of OsmoPrep was evaluated in a randomized, investigator-blinded, actively controlled, multicenter, U. In Study 1, patients were randomized into one of the following three sodium phosphate treatment groups:. Patients were instructed to eat a light breakfast before noon on the day prior to the colonoscopy and then were told to drink only clear liquids after noon on the day prior to the colonoscopy.

The primary efficacy endpoint was the overall colon cleansing response rate in the 4-point Colonic Contents Scale. This trial was designed to assess the non-inferiority of the two OsmoPrep groups compared to the active control group. The efficacy analysis included adult patients who had an elective colonoscopy.

The OsmoPrep gram and gram treatment groups demonstrated non-inferiority compared to the active control. See Table 2 for the results. The OsmoPrep gram dosage regimen had a similar overall response rate as the gram dosage regimen and was associated with an increased risk of adverse reactions [see Adverse Reactions 6. OsmoPrep is packaged in a multi-dose, child-resistant bottle containing tablets: NDC Patent Number: 7,, and other pending applications.

Read this Medication Guide before you start taking OsmoPrep. This information does not take the place of talking with your doctor about your medical condition or your treatment.

What is the most important information I should know about OsmoPrep? Serious kidney problems. Rare, but serious kidney problems can happen in people who take medicines made with sodium phosphate, including OsmoPrep, to clean the colon before colonoscopy. These kidney problems can sometimes lead to kidney failure or the need for dialysis for a long time. These problems often happen within a few days, but sometimes may happen several months after taking OsmoPrep.

Conditions that can make you more at risk for having serious kidney problems with OsmoPrep include if you:. Severe fluid loss dehydration and severe changes in body salts in the blood electrolytes. People who take medicines to clean their colon before a colonoscopy, including OsmoPrep, can have severe loss of body fluid, with severe changes in body salts in the blood.

These changes can be serious and can cause:. Tell your doctor if you have any of these symptoms of loss of too much body fluid dehydration while taking OsmoPrep:. OsmoPrep is a prescription medicine used in adults to clean your colon before a colonoscopy.

OsmoPrep cleans your colon by causing you to have diarrhea. Cleaning your colon helps your doctor see the inside of your colon more clearly during the colonoscopy. Before you take OsmoPrep, tell your doctor about all of your medical conditions, including if you:. Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

OsmoPrep may affect how other medicines work. Do not take medicines by mouth within 1 hour of starting each dose of OsmoPrep or 1 hour after you start taking each dose of OsmoPrep.

Know the medicines you take. Keep a list of your medicines to show your doctor or pharmacist when you get a new prescription. On the day of your colonoscopy, take a total of 12 OsmoPrep tablets, starting about 3 to 5 hours before your colonoscopy, as follows:.

If you take too much OsmoPrep, call your doctor or get medical help right away. These are not all the possible side effects of OsmoPrep. For more information, ask your doctor or pharmacist. Tell your doctor if you have any of these symptoms of loss of too much body fluid dehydration while taking OsmoPrep:. OsmoPrep is a prescription medicine used in adults 18 years and older, to clean your colon before a colonoscopy.

OsmoPrep cleans your colon by causing you to have diarrhea. Cleaning your colon helps your doctor see the inside of your colon more clearly during the colonoscopy. Tell your doctor about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. Any medicine that you take close to the time that you take OsmoPrep may not work as well. Especially tell your doctor if you take:. Ask your doctor if you are not sure if your medicine is listed above.

Know the medicines you take. Keep a list of your medicines to show your doctor or pharmacist when you get a new prescription. You must read, understand, and follow these instructions to take OsmoPrep the right way:. On the evening before your colonoscopy you will take a total of 20 OsmoPrep tablets, as follows:. On the day of your colonoscopy you will take a total of 12 OsmoPrep tablets, starting about 3 to 5 hours before your colonoscopy, as follows:.

If you take too much OsmoPrep, call your doctor or get medical help right away. These are not all the possible side effects of OsmoPrep. For more information, ask your doctor or pharmacist.

Call your doctor for medical advice about side effects. Medicines are sometimes prescribed for purposes other than those listed in a Medication Guide. Do not use OsmoPrep for a condition for which it was not prescribed. Do not give OsmoPrep to other people, even if they have the same symptoms that you have.

It may harm them. This Medication Guide summarizes the most important information about OsmoPrep. If you would like more information about OsmoPrep, talk with your doctor or pharmacist.

You can ask your doctor or pharmacist for information that is written for healthcare professionals. For more information, call toll-free or go to www. Active ingredients: sodium phosphate monobasic monohydrate and sodium phosphate dibasic anhydrous.